NEURALSTEM ANNOUNCES PRESENTATION OF PRECLINICAL DATA DEMONSTRATING NEUROGENIC COMPOUND NSI-189 IMPR

• Study evaluated the effect of oral treatment with NSI-189 in well-established 5xFAD mouse model for Alzheimer’s disease (AD)

• Treatment with NSI-189 restored memory retention and learning abilities in AD mice, and reduced anxiety in control and AD mice

GERMANTOWN, Md., July 24 (Bernama-GLOBE NEWSWIRE) -- Neuralstem, Inc. (Nasdaq:CUR), a biopharmaceutical company developing novel treatments for nervous system diseases, today announced the presentation of data at the Alzheimer's Association International Conference in Chicago, Illinois, demonstrating that oral administration of NSI-189 in a mouse model of Alzheimer’s Disease leads to a significant amelioration and/or improvement in cognition measures and anxiety. Results are being presented in a poster titled ‘Effect of Neurogenic Compound NSI-189 on Indices of Cognition and Anxiety in a Mouse Model (5XFAD) of Alzheimer’s Disease.’ The study was carried out by Dr. Corinne Jolivalt’s laboratory at the University of California, San Diego, and involved the oral administration of NSI-189 to mice harboring gene changes that recreate symptoms of familial Alzheimer’s disease. Animals were treated starting at 15 weeks of age, when memory defects are first beginning to appear. Key findings include:

• Treatment with NSI-189 significantly improved learning ability as well as retention as measured by a simple task (Barnes maze), and improved performance on a test of short term memory (Novel Object Recognition)

• Treatment with NSI-189 improved motor learning of AD mice as measured by performance on a Rotarod test

• NSI-189 treatment decreased anxiety levels in both AD mice and control mice as measured by an open field test

“Data from this preclinical study suggest that NSI-189 may be able to mitigate or reverse the cognitive impact of Alzheimer’s disease,” said Corinne Jolivalt, PhD, associate professor in the Department of Pathology at UC San Diego School of Medicine. “We look forward to continuing this line of inquiry to further evaluate the potential of NSI-189 in the treatment of this devastating disease.” About Alzheimer’s disease Alzheimer's disease is a chronic, neurodegenerative disorder that causes progressive dementia as well as a decline in other aspects of cognition which can affect a person’s ability to interact socially or function at work. There are currently an estimated 50 million people living with dementia around the world, with numbers expected to triple by 2050. The total estimated annual social and economic cost of dementia is $818 billion USD worldwide and is expected to reach a trillion in the coming years.

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